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KMID : 1202020100030020142
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Journal of Korean Thyroid Association
2010 Volume.3 No. 2 p.142 ~ p.148
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Prevalence of Thyroid Nodules and Cancer Detected by Ultrasonography in Healthy Korean Adults: Clinical Features and the Risk for Malignancy
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Oh Eun-Yeong
Jang Hye-Won
Lee Ji-In
Kim Hee-Kyung
Kim Sun-Wook
Chung Jae-Hoon
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Abstract
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Background and Objectives :The prevalence of thyroid nodules has been reported to be high; however, it varies depending on the region and method of the study. We evaluated the prevalence of thyroid nodules detected by high-frequency ultrasonography (USG) in healthy Korean adults and analyzed its association with age, gender, size, multiplicity, and malignancy.
Materials and Methods :We reviewed the medical records of 15,415 subjects (1,951 men and 13,464 women) that presented to our hospital for a health check-up from 2003 to 2005, and underwent a thyroid USG. Among them, USG-guided fine-needle aspiration cytology (FNAC) was performed in 1,659 subjects (10.7%) that had indeterminate or suspicious malignant nodules on USG.
Results: Among the 15,415 subjects, thyroid solid nodules were found in 6,023 (39.1%) by USG. The prevalence of thyroid nodules and multiplicity significantly increased with age (p＜0.05), but did not differ by gender. Thyroid cancer was detected in 385 subjects (2.5%) by FNAC or by histological examination. The prevalence of thyroid cancer was 6.4% among the subjects with thyroid nodules. It did not differ by gender and nodule size. It tended to increase with age in total subjects, but was not significant. In the subjects with thyroid nodules, the risk of malignancy was highest in subjects aged under 40 and then decreased with age and higher in subjects with multiple nodules (p＜0.05).
Conclusion: The prevalence of thyroid nodules was 39.1% and the risk of malignancy in subjects with nodules was higher in subjects with younger age or multiple nodules.
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KEYWORD
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Prevalence, Thyroid nodule, Thyroid cancer
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